Bioactivities and Iridoid Determination of a Beverage Containing Noni, Cornelian Cherries and Olive Leaf Extract

The aim of the current study was to evaluate the iridoid content, as well as the in vitro and in vivo bioactivities, of a beverage containing noni fruit, Cornelian cherries, and olive leaf extract (Thrive Adaptogenics Max). The average total iridoid content of the beverage was 2.09 mg/mL. The major iridoids present were identified as asperulosidic acid, deacetylasperulosidic acid, oleuropein, morroniside, loganic acid, and loganin. In the 2, 2-Diphenylpicrylhydrazyl (DPPH) radical scavenging assay, remarkably high in vitro antioxidant activity was observed, with an IC50 of 3.8 :L/mL. In vivo bioactivities were evaluated in type 2 diabetic Sprague Dawley rats. In a dose-dependent manner, Thrive Adaptogenics Max reduced abnormal weight gain, blood glucose levels, and serum Advanced Glycation End products (AGEs), as well as improved immunity via increased T cell counts and CD4/CD8ratios. These results suggest that this blend of ingredients is beneficial for improving and maintaining health in the general population, as well as among those with metabolic imbalance.